Tbx1^{tm4(cre/Esr1*)Bld}
Targeted Allele Detail

Summary

• Symbol: Tbx1^{tm4(cre/Esr1*)Bld}
• Name: T-box 1; targeted mutation 4, Antonio Baldini
• MGI ID: MGI:3046795
• Synonyms: Tbx1^mcm, Tbx1^{tm4(cre/Esr1)Bld}
• Gene: Tbx1 Location: Chr16:18399729-18409412 bp, - strand Genetic Position: Chr16, Syntenic
• Alliance: Tbx1^{tm4(cre/Esr1*)Bld} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91013
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tbx1^{tm4(cre/Esr1*)Bld} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tbx1 (MGI:98493)

• Mutation details: An IRES and MerCreMer fusion gene were inserted into exon 5 via homologous recombination. This is the same insertion site as in Tbx1^tm1Bld. This results in tamoxifen-inducible cre expression under the control of the endogenous Tbx1 promoter. (J:91013)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tbx1 (mouse) Summary of all recombinase alleles driven by Tbx1. Comparative matrix view of recombinase activities Alliance mouse Tbx1 gene page

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tbx1 Mutation: 36 strains or lines available

References

• Original: J:91013 Xu H, et al., Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract. Development. 2004 Jul;131(13):3217-27
• All: 10 reference(s)