Parp4^tm1Leah
Targeted Allele Detail

Summary

• Symbol: Parp4^tm1Leah
• Name: poly (ADP-ribose) polymerase family, member 4; targeted mutation 1, Lea Harrington
• MGI ID: MGI:3046826
• Synonyms: mVparp^-, Vparp^-
• Gene: Parp4 Location: Chr14:56813076-56897251 bp, + strand Genetic Position: Chr14, 28.31 cM
• Alliance: Parp4^tm1Leah page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91080
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 and 4, which include the predicted PARP catalytic domain, were replaced with a PGK-neo cassette. Northern analysis showed no transcripts and Western blot indicated lack of protein in mutant MEFs. (J:91080)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Parp4 Mutation: 90 strains or lines available

References

• Original: J:91080 Liu Y, et al., Vault poly(ADP-ribose) polymerase is associated with mammalian telomerase and is dispensable for telomerase function and vault structure in vivo. Mol Cell Biol. 2004 Jun;24(12):5314-23
• All: 2 reference(s)