Map3k5^tm1Hijo
Targeted Allele Detail

Summary

• Symbol: Map3k5^tm1Hijo
• Name: mitogen-activated protein kinase kinase kinase 5; targeted mutation 1, Hidenori Ichijo
• MGI ID: MGI:3046838
• Synonyms: ASK-, ASK1^-
• Gene: Map3k5 Location: Chr10:19810218-20018499 bp, + strand Genetic Position: Chr10, 9.35 cM
• Alliance: Map3k5^tm1Hijo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88612
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding region of exon 1 was replaced with a cassette containing GFP and PGK-neo. The absence of normal protein from homozygous mutant mice was indicated by both Western blot analysis of MEFs and immune complex kinase assay of various tissues and MEFs. (J:88612)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Map3k5 Mutation: 61 strains or lines available

References

• Original: J:88612 Tobiume K, et al., ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis. EMBO Rep. 2001 Mar;2(3):222-8
• All: 59 reference(s)