Lpolv^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Lpolv^DBA/2J
• Name: lipid peroxidation in liver; DBA/2J
• MGI ID: MGI:3046901
• QTL: Lpolv Location: unknown Genetic Position: Chr8, Syntenic

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:73733

Linkage analysis was performed on 20 BXD (B=C57BL/6J; D=DBA/2J) recombinant inbred (RI) strains to identify QTLs associated with lipid peroxidation (LPO) in the liver as a function of aging. Liver peroxidation increases with age but is significantly increased in DBA/2J compared to C57BL/6J. LPO increases 50% in 23-month old C57BL/6J animals compared to 2-month old animals, but LPO increases 400% in 23-month old DBA/2J animals compared to 2-month old animals.

Linkage to LPO was detected at 55.2 cM on mouse Chromosome 8 near Zfp4 (P<0.0006). This QTL is named Lpolv (lipid peroxidation in liver). Two potential candidate genes for this locus are Lcat (53 cM) and Nqo1 (53.3 cM). However, sequence analysis of regions of Lcat and Nqo1 did not reveal polymorphisms between C57BL/6J and DBA/2J.

References

• Original: J:73733 Gerhard GS, et al., Genetic differences in hepatic lipid peroxidation potential and iron levels in mice. Mech Ageing Dev. 2002 Jan;123(2-3):167-76
• All: 1 reference(s)