Tg(hREN)9Sig
Transgene Detail

Summary

• Symbol: Tg(hREN)9Sig
• Name: transgene insertion 9, Curt Sigmund
• MGI ID: MGI:3046926
• Synonyms: hR, R+
• Transgene: Tg(hREN)9Sig Location: unknown Genetic Position: ChrX, Syntenic
• Alliance: Tg(hREN)9Sig page

Transgene origin

• Strain of Origin: (C57BL/10Ros x C3H/HeRos)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(hREN)9Sig expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  REN (5972)

  Ren1	(MGI:97898)
  Ren2	(MGI:97899)

• Mutation details: The transgene contained the entire human renin gene. Active renin is released into the plasma, and high levels of human renin expression are detected in kidney, adrenal gland, ovary, testis, lung and adipose tissue. Expression of human renin is not detected in liver or brain. (J:81877)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:81877 Sigmund CD, et al., Regulated tissue- and cell-specific expression of the human renin gene in transgenic mice. Circ Res. 1992 May;70(5):1070-9
• All: 25 reference(s)