Hprt1^{tm2(UAS-Bmp4)Bhr}
Targeted Allele Detail

Summary

• Symbol: Hprt1^{tm2(UAS-Bmp4)Bhr}
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 2, Richard R Behringer
• MGI ID: MGI:3046927
• Synonyms: UAS-mutBmp4
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^{tm2(UAS-Bmp4)Bhr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91296
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Inducible, Inserted expressed sequence)
• Inducer: not specified
• Mutation: Insertion
• Hprt1^{tm2(UAS-Bmp4)Bhr} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Bmp4 (MGI:88180)

• Mutation details: A UAS-mutBmp4-SV40pA-floxed neo was inserted into exon 3. mutBmp4 contained a deletion of 15 nucleotides from position 901-915, the sequence encoding the amino acids RSRKK that precede the first cysteine of the mature protein. Southern blot confirmed recombination. (J:91296)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1279 strains or lines available

References

• Original: J:91296 Hu Q, et al., Restriction of BMP4 activity domains in the developing neural tube of the mouse embryo. EMBO Rep. 2004 Jul;5(7):734-9
• All: 1 reference(s)