Nfkbiz^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Nfkbiz^tm1Aki
• Name: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:3046930
• Synonyms: IkappaBzeta^-
• Gene: Nfkbiz Location: Chr16:55631740-55659018 bp, - strand Genetic Position: Chr16, 33.65 cM, cytoband C1.2-C1.3
• Alliance: Nfkbiz^tm1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91297
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The sequence encoding the central portion of the gene was replaced with a neo cassette. Northern blot indicated absence of transcript and Western blot showed no protein present in mutants. (J:91297)

Disease models

Expression

In Structures Affected by this Mutation:

12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nfkbiz Mutation: 33 strains or lines available

References

• Original: J:91297 Yamamoto M, et al., Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta. Nature. 2004 Jul 8;430(6996):218-22
• All: 15 reference(s)