Hyou1^tm1Oga
Targeted Allele Detail

Summary

• Symbol: Hyou1^tm1Oga
• Name: hypoxia up-regulated 1; targeted mutation 1, Satoshi Ogawa
• MGI ID: MGI:3046998
• Gene: Hyou1 Location: Chr9:44290840-44303662 bp, + strand Genetic Position: Chr9, 24.84 cM, cytoband B
• Alliance: Hyou1^tm1Oga page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91396
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neo cassette replaced exons 8-10 via homologous recombination. Southern blot confirmed successful recombination. Immunoblotting of heterozygous mice indicated presence of the full-length protein only and not the predicted 226 amino acid long truncated protein, indicating that the mutation results in a null allele. (J:91396)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hyou1 Mutation: 37 strains or lines available

References

• Original: J:91396 Kitao Y, et al., Expression of the endoplasmic reticulum molecular chaperone (ORP150) rescues hippocampal neurons from glutamate toxicity. J Clin Invest. 2001 Nov;108(10):1439-50
• All: 8 reference(s)