Tg(Mpz-cre)2Brn
Transgene Detail

Summary

• Symbol: Tg(Mpz-cre)2Brn
• Name: transgene insertion 2, Anton Berns
• MGI ID: MGI:3047001
• Synonyms: P0Cre^B
• Transgene: Tg(Mpz-cre)2Brn Location: unknown
• Alliance: Tg(Mpz-cre)2Brn page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Mpz-cre)2Brn expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Mpz (24564)

  Mpz	(MGI:103177)

• Mutation details: The bacteriophage P1 Cre recombinase is driven by a 1.1 kb promoter fragment of the rat Mpz gene (myelin protein zero, P0). Lines 1-4 (A-D) showed a single integration of the transgene. Further characterization was carried out for lines 1-3 (A-C). (J:63264)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Mpz (rat) Summary of all recombinase alleles driven by Mpz. Comparative matrix view of recombinase activities Alliance rat Mpz gene page

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Tg(Mpz-cre)2Brn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Four founders were originally designated as P0Cre^A-D.

References

• Original: J:63264 Giovannini M, et al., Conditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2. Genes Dev. 2000 Jul 1;14(13):1617-30
• All: 3 reference(s)