Prnp/Prnd^tm1Dwm
Targeted Allele Detail

Summary

• Symbol: Prnp/Prnd^tm1Dwm
• Name: prion protein; targeted mutation 1, David W Melton
• MGI ID: MGI:3047062
• Synonyms: Prnp^-/Prnd^-
• Gene: Prnp Location: Chr2:131751848-131780349 bp, + strand Genetic Position: Chr2, 64.07 cM
• Alliance: Prnp/Prnd^tm1Dwm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91094
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Mutation details: Both coding regions were ablated by replacement with an Hprt minigene. Western blot of mutant testes lysates show absence of both proteins. (J:91094)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prnp Mutation: 142 strains or lines available

References

• Original: J:91094 Paisley D, et al., Male infertility and DNA damage in Doppel knockout and prion protein/Doppel double-knockout mice. Am J Pathol. 2004 Jun;164(6):2279-88
• All: 1 reference(s)