Cacna1c^tm1Jst
Targeted Allele Detail

Summary

• Symbol: Cacna1c^tm1Jst
• Name: calcium channel, voltage-dependent, L type, alpha 1C subunit; targeted mutation 1, Jorg Striessnig
• MGI ID: MGI:3047071
• Synonyms: Cav1.2DHP^-
• Gene: Cacna1c Location: Chr6:118564201-119173851 bp, - strand Genetic Position: Chr6, 55.86 cM
• Alliance: Cacna1c^tm1Jst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91092
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A floxed neo was inserted upstream of a mutagenized exon 24 containing T1066Y, that encodes regions of the alpha 1 subunit. Crossing with deleter mice excised the floxed neo in the germ line, leaving the mutation in exon 24. Southern blot confirmed recombination and Western blot of brain and heart membranes showed no affects of the mutation on gene expression density. (J:91092)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cacna1c Mutation: 144 strains or lines available

References

• Original: J:91092 Sinnegger-Brauns MJ, et al., Isoform-specific regulation of mood behavior and pancreatic beta cell and cardiovascular function by L-type Ca 2+ channels. J Clin Invest. 2004 May;113(10):1430-9
• All: 10 reference(s)