Myb^tm1.1Cgn
Targeted Allele Detail

Summary

• Symbol: Myb^tm1.1Cgn
• Name: myeloblastosis oncogene; targeted mutation 1.1, University of Cologne
• MGI ID: MGI:3047076
• Synonyms: Myb^-, Myb^d
• Gene: Myb Location: Chr10:21000834-21036883 bp, - strand Genetic Position: Chr10, 9.75 cM
• Alliance: Myb^tm1.1Cgn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91122
• Parent Cell Line: IB10/E14IB10 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Crossing of Myb^tm1Cgn with mice expressing Cre under the control of an hCMV promoter excised floxed exon 2, leaving a single loxP site. Southern blot confirmed recombination and Western blot of fetal livers showed lack of protein in mutants. (J:91122)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myb Mutation: 53 strains or lines available

References

• Original: J:91122 Bender TP, et al., Critical functions for c-Myb at three checkpoints during thymocyte development. Nat Immunol. 2004 Jul;5(7):721-9
• All: 8 reference(s)