Kit^W-vkd
Spontaneous Allele Detail

Summary

• Symbol: Kit^W-vkd
• Name: KIT proto-oncogene receptor tyrosine kinase; vickid
• MGI ID: MGI:3047218
• Synonyms: VIable C-Kit Deficient
• Gene: Kit Location: Chr5:75735647-75817382 bp, + strand Genetic Position: Chr5, 39.55 cM
• Alliance: Kit^W-vkd page

Mutation origin

• Strain of Origin: STOCK Kit^W

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: The complete molecular nature of this allele has not yet been determined. Restriction site analysis and sequenceing identified the W mutation in which a G-to-A transition exists in the splice donor site of exon 10-intron 10 (changing it from G-GT to G-AT), resulting in the aberrant splicing of exon 9 to 11, skipping exon 10 which encodes the transmembrane domain. Protein produced from this allele could not be discerned from the product of the Kit^W allele by immunoprecipitation. (J:79128)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kit Mutation: 182 strains or lines available

References

• Original: J:79128 Waskow C, et al., Viable c-Kit(W/W) Mutants Reveal Pivotal Role for c-Kit in the Maintenance of Lymphopoiesis. Immunity. 2002 Sep;17(3):277
• All: 1 reference(s)