Tg(PDGFB-EPO)321Zbz
Transgene Detail

Summary

• Symbol: Tg(PDGFB-EPO)321Zbz
• Name: transgene insertion 321, University of Zurich
• MGI ID: MGI:3047261
• Synonyms: Tg6, TgN(PDFGBEPO)321Zbz, TgN(PDGFBEPO)321Zbz, Tg(PDGFB-EPO)321Gass
• Transgene: Tg(PDGFB-EPO)321Zbz Location: unknown
• Alliance: Tg(PDGFB-EPO)321Zbz page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(PDGFB-EPO)321Zbz expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  EPO (2056)

  Epo	(MGI:95407)

• Mutation details: The transgenic construct consisted of the human erythropoietin cDNA adjoined to the human platelet derived growth factor B promoter. EPO protein was detected in the brain and in plasma where it showed a 10 fold increase. (J:65257)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:65257 Ruschitzka FT, et al., Nitric oxide prevents cardiovascular disease and determines survival in polyglobulic mice overexpressing erythropoietin. Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11609-13
• All: 31 reference(s)