Tg(Mpz-cre)4Brn
Transgene Detail

Summary

• Symbol: Tg(Mpz-cre)4Brn
• Name: transgene insertion 4, Anton Berns
• MGI ID: MGI:3047266
• Synonyms: P0Cre^D
• Transgene: Tg(Mpz-cre)4Brn Location: unknown
• Alliance: Tg(Mpz-cre)4Brn page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Mpz-cre)4Brn expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Mpz

• Mutation details: The bacteriophage P1 Cre recombinase is driven by a 1.1 kb promoter fragment of the rat Mpz gene (myelin protein zero, P0). Lines 1-4 (A-D) showed a single integration of the transgene. (J:63264)

Recombinase activity

Activity:	Tissue activity of this recombinase allele MGI has not yet included tissue activity data for this allele in any anatomical systems.
Driver:	Mpz (species not specified) Summary of all recombinase alleles driven by Mpz.

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cn1	Nf2^tm2Gth/Nf2^tm2Gth Tg(Mpz-cre)4Brn/0	involves: 129P2/OlaHsd * FVB/N
cn2	Nf2^tm1Gth/Nf2^tm2Gth Tg(Mpz-cre)4Brn/0	involves: 129P2/OlaHsd * FVB/N

Phenotypes:

Affected Systems	cn1	cn2
show or hide all annotated terms
mortality/aging	√	√
decreased survivor rate	√	√
premature death	√
neoplasm	√
increased Schwannoma incidence	√
nervous system	√
increased Schwannoma incidence	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Four founders were originally designated as P0Cre^A-D.

References

• Original: J:63264 Giovannini M, et al., Conditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2. Genes Dev. 2000 Jul 1;14(13):1617-30
• All: 1 reference(s)