Aplnr^tm1Afu
Targeted Allele Detail

Summary

• Symbol: Aplnr^tm1Afu
• Name: apelin receptor; targeted mutation 1, Akiyoshi Fukamizu
• MGI ID: MGI:3047284
• Synonyms: APJ^-
• Gene: Aplnr Location: Chr2:84966704-84970267 bp, + strand Genetic Position: Chr2, 49.45 cM, cytoband E1
• Alliance: Aplnr^tm1Afu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91164
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A promoterless lacZ gene and a neomycin resistance gene replaced a portion of the coding sequence. Southern blot confirmed homologous recombination and Northern blot of mutant heart and lung indicated no transcript was present. (J:91164)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aplnr Mutation: 30 strains or lines available

References

• Original: J:91164 Ishida J, et al., Regulatory roles for APJ, a seven-transmembrane receptor related to angiotensin-type 1 receptor in blood pressure in vivo. J Biol Chem. 2004 Jun 18;279(25):26274-9
• All: 10 reference(s)