Abcc4^tm1Jsch
Targeted Allele Detail

Summary

• Symbol: Abcc4^tm1Jsch
• Name: ATP-binding cassette, sub-family C member 4; targeted mutation 1, John D Schuetz
• MGI ID: MGI:3047326
• Synonyms: Mrp4^-
• Gene: Abcc4 Location: Chr14:118720104-118943631 bp, - strand Genetic Position: Chr14, 62.24 cM
• Alliance: Abcc4^tm1Jsch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90692
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced exon 27. Immunoblot analysis of membrane fractions showed complete loss of protein in mutants. (J:92788)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Abcc4 Mutation: 153 strains or lines available

References

• Original: J:90692 Assem M, et al., Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice. J Biol Chem. 2004 May 21;279(21):22250-7
• All: 20 reference(s)