Cyp17a1^tm1Mell
Targeted Allele Detail

Summary

• Symbol: Cyp17a1^tm1Mell
• Name: cytochrome P450, family 17, subfamily a, polypeptide 1; targeted mutation 1, Synthia H Mellon
• MGI ID: MGI:3047328
• Synonyms: P450c17^-
• Gene: Cyp17a1 Location: Chr19:46655604-46661439 bp, - strand Genetic Position: Chr19, 38.97 cM
• Alliance: Cyp17a1^tm1Mell page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91081
• Parent Cell Line: JM-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 5 and all of exon 6 were replaced with a neo. Exon 6 contains the Ozols peptide, which comprises amino acids 346 to 366 and contains amino acids crucial for redox partner binding. Immunostaining of embryos revealed absence of protein in homozygous mutants. (J:91081)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyp17a1 Mutation: 24 strains or lines available

References

• Original: J:91081 Bair SR, et al., Deletion of the mouse P450c17 gene causes early embryonic lethality. Mol Cell Biol. 2004 Jun;24(12):5383-90
• All: 2 reference(s)