Ptprcap^tm1Svn
Targeted Allele Detail

Summary

• Symbol: Ptprcap^tm1Svn
• Name: protein tyrosine phosphatase receptor type C polypeptide-associated protein; targeted mutation 1, Burkhart Schraven
• MGI ID: MGI:3047383
• Synonyms: Lpap^-
• Gene: Ptprcap Location: Chr19:4204645-4206709 bp, + strand Genetic Position: Chr19, 3.86 cM, cytoband B
• Alliance: Ptprcap^tm1Svn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:58712
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2, which comprises the majority of the coding sequence, was replaced with a neo cassette. Southern blot and PCR confirmed recombination and RT-PCR and Western blot indicated lack of transcript and protein, respectively. (J:58712)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptprcap Mutation: 20 strains or lines available

Notes

ES cell line = EL-1.

References

• Original: J:58712 Ding I, et al., Biochemical and functional analysis of mice deficient in expression of the CD45-associated phosphoprotein LPAP. Eur J Immunol. 1999 Dec;29(12):3956-61
• All: 1 reference(s)