Il31ra^tm1Jagr
Targeted Allele Detail

Summary

• Symbol: Il31ra^tm1Jagr
• Name: interleukin 31 receptor A; targeted mutation 1, Jane A Gross
• MGI ID: MGI:3047479
• Synonyms: IL-31RA KO
• Gene: Il31ra Location: Chr13:112649439-112717266 bp, - strand Genetic Position: Chr13, 63.75 cM
• Alliance: Il31ra^tm1Jagr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91124
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 3.4 kb segment including exons 4-6 was replaced with IRESbGal-PolyA-MC1neo-PolyA selectable marker cassette via homologous recombination. RT-PCR confirmed the absence of RNA in the skin, lung and colons of homozygous mutant mice. (J:91124)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il31ra Mutation: 84 strains or lines available

References

• Original: J:91124 Dillon SR, et al., Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. Nat Immunol. 2004 Jul;5(7):752-60
• All: 4 reference(s)