Cd79a^tm5.1Cgn
Targeted Allele Detail

Summary

• Symbol: Cd79a^tm5.1Cgn
• Name: CD79A antigen (immunoglobulin-associated alpha); targeted mutation 5.1, University of Cologne
• MGI ID: MGI:3047539
• Synonyms: Igalpha^deltaC1
• Gene: Cd79a Location: Chr7:24596922-24601283 bp, + strand Genetic Position: Chr7, 13.49 cM
• Alliance: Cd79a^tm5.1Cgn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91091
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Crossing Cd79a^tm5Cgn mice with deleter mice expressing cre in the germline created this allele in which floxed exon 4 was excised, thereby eliminating the membrane-proximal part of the cytoplasmic tail and disrupting the ITAM motif. Flow cytometry revealed severely impaired B cell development, with bone marrow numbers of immature and mature B cells being about 10 and 100 times lower than in wild-type controls. (J:91091)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd79a Mutation: 24 strains or lines available

References

• Original: J:91091 Kraus M, et al., Survival of resting mature B lymphocytes depends on BCR signaling via the Igalpha/beta heterodimer. Cell. 2004 Jun 11;117(6):787-800
• All: 2 reference(s)