Tg(Cr2-cre)3Cgn
Transgene Detail

Summary

• Symbol: Tg(Cr2-cre)3Cgn
• Name: transgene insertion 3, University of Cologne
• MGI ID: MGI:3047571
• Synonyms: CD21-cre, CD21-cre3a, Cr2^tm1(cre)Cgn
• Transgene: Tg(Cr2-cre)3Cgn Location: unknown
• Alliance: Tg(Cr2-cre)3Cgn page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Cr2-cre)3Cgn expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Cr2

• Mutation details: This transgene consists of a cre expression cassette including a Kozak sequence, nuclear localization signal, and bovine growth hormone polyadenylation signal inserted into a BAC containing the Cr2 locus. The ATG in the first exon of Cr2 is also mutated in this allele. Cre mediated recombination is detected in 60% - 80% of mature B cells and is undetectable in pro/pre-B and immature B cells. (J:91091)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cr2 (species not specified) Summary of all recombinase alleles driven by Cr2. Comparative matrix view of recombinase activities

Tumor Data

List all tumor models in MMHCdb carrying Tg(Cr2-cre)3Cgn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:91091 Kraus M, et al., Survival of resting mature B lymphocytes depends on BCR signaling via the Igalpha/beta heterodimer. Cell. 2004 Jun 11;117(6):787-800
• All: 78 reference(s)