Prnp/Prndtm1Aag
Targeted Allele Detail
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Symbol: |
Prnp/Prndtm1Aag |
Name: |
prion protein; targeted mutation 1, Adriano Aguzzi |
MGI ID: |
MGI:3047635 |
Synonyms: |
Prno |
Gene: |
Prnp Location: Chr2:131751848-131780349 bp, + strand Genetic Position: Chr2, 64.07 cM
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Alliance: |
Prnp/Prndtm1Aag page
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Germline Transmission: |
Earliest citation of germline transmission:
J:89232
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Parent Cell Line: |
E14.1 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Intergenic deletion
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Mutation details: Using transalleleic targeted meiotic recombination, this allele was created in which both the Prnd and Prnp loci are disrupted. The recombined allele lacks ~16 kb encompassing both genes. To generate this allele, Prnptm2.1Cwe mice, which have a loxP site in place of the coding sequence, were crossed with Prndtm1Aag mice, which have a floxed neo in place of the coding exon. Northern blot analysis indicated absence of Prnp and Prnd transcript in brain, spleen and testes of mutants.
(J:89232)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Prnp Mutation: |
142 strains or lines available
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Original: |
J:89232 Genoud N, et al., Disruption of Doppel prevents neurodegeneration in mice with extensive Prnp deletions. Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4198-203 |
All: |
3 reference(s) |
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