Klf2^tm1Ling
Targeted Allele Detail

Summary

• Symbol: Klf2^tm1Ling
• Name: Kruppel-like transcription factor 2 (lung); targeted mutation 1, Jerry B Lingrel
• MGI ID: MGI:3047647
• Synonyms: LKLF-
• Gene: Klf2 Location: Chr8:73072906-73075498 bp, + strand Genetic Position: Chr8, 34.99 cM, cytoband C1
• Alliance: Klf2^tm1Ling page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:51402
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An expression cassette of the hypoxanthine phosphoriboyltrasferase (HPRT) gene replaced the promoter region, and sequences encoding the transcription activation domain and part of the DNA binding domain of the gene. Northern and RT-PCR analysis showed that a null allele was obtained. (J:51402)

Expression

In Mice Carrying this Mutation:	28 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klf2 Mutation: 12 strains or lines available

References

• Original: J:51402 Wani MA, et al., Loss of LKLF function results in embryonic lethality in mice. Transgenic Res. 1998 Jul;7(4):229-38
• All: 17 reference(s)