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Hprt1tm1Dhm
Targeted Allele Detail
Summary
Symbol: Hprt1tm1Dhm
Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, David H MacLennan
MGI ID: MGI:3050087
Synonyms: NF-SLN
Gene: Hprt1  Location: ChrX:52077014-52110536 bp, + strand  Genetic Position: ChrX, 29.31 cM, cytoband A6
Alliance: Hprt1tm1Dhm page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:91410
Parent Cell Line:  BK4 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsA construct containing part of the Hprt promoter, the alpha-myosin heavy-chain promoter, rabbit NF-SLN cDNA, pA, and Hprt sequence containing exons 1-3 was inserted into ES cells lacking Hprt promoter and exons 1 and 2. Successful recombination was confirmed by PCR. (J:91410)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hprt1 Mutation:  1279 strains or lines available
References
Original:  J:91410 Asahi M, et al., Cardiac-specific overexpression of sarcolipin inhibits sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA2a) activity and impairs cardiac function in mice. Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9199-204
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory