Hprt1tm1Dhm
Targeted Allele Detail
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Symbol: |
Hprt1tm1Dhm |
Name: |
hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, David H MacLennan |
MGI ID: |
MGI:3050087 |
Synonyms: |
NF-SLN |
Gene: |
Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
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Alliance: |
Hprt1tm1Dhm page
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Germline Transmission: |
Earliest citation of germline transmission:
J:91410
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Parent Cell Line: |
BK4 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Inserted expressed sequence) |
Mutation: |
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Insertion
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Mutation details: A construct containing part of the Hprt promoter, the alpha-myosin heavy-chain promoter, rabbit NF-SLN cDNA, pA, and Hprt sequence containing exons 1-3 was inserted into ES cells lacking Hprt promoter and exons 1 and 2. Successful recombination was confirmed by PCR.
(J:91410)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Hprt1 Mutation: |
1279 strains or lines available
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Original: |
J:91410 Asahi M, et al., Cardiac-specific overexpression of sarcolipin inhibits sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA2a) activity and impairs cardiac function in mice. Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9199-204 |
All: |
2 reference(s) |
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