About   Help   FAQ
Hprt1tm1Dhm
Targeted Allele Detail
Summary
Symbol: Hprt1tm1Dhm
Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, David H MacLennan
MGI ID: MGI:3050087
Synonyms: NF-SLN
Gene: Hprt1  Location: ChrX:52077014-52110536 bp, + strand  Genetic Position: ChrX, 29.31 cM, cytoband A6
Alliance: Hprt1tm1Dhm page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:91410
Parent Cell Line:  BK4 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsA construct containing part of the Hprt promoter, the alpha-myosin heavy-chain promoter, rabbit NF-SLN cDNA, pA, and Hprt sequence containing exons 1-3 was inserted into ES cells lacking Hprt promoter and exons 1 and 2. Successful recombination was confirmed by PCR. (J:91410)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hprt1 Mutation:  1279 strains or lines available
References
Original:  J:91410 Asahi M, et al., Cardiac-specific overexpression of sarcolipin inhibits sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA2a) activity and impairs cardiac function in mice. Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9199-204
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory