Pparg^tm1Mae
Targeted Allele Detail

Summary

• Symbol: Pparg^tm1Mae
• Name: peroxisome proliferator activated receptor gamma; targeted mutation 1, Nobuyo Maeda
• MGI ID: MGI:3050095
• Synonyms: PPARgamma^L, PPAR-gamma^P465L, Pparg^P465L
• Gene: Pparg Location: Chr6:115337912-115467360 bp, + strand Genetic Position: Chr6, 53.41 cM, cytoband E3-F1
• Alliance: Pparg^tm1Mae page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91362
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Dominant negative, Humanized sequence)
• Mutation: Nucleotide substitutions
• Mutation details: A missense mutation was introduced to replace proline at position 465 in exon 6 with leucine (P465L). An ACN cassette containing a testis-specific Ace promoter, Cre recombinase and Neo-resistance gene was excised upon germline transmission. Southern blot confirmed recombination. (J:91362)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pparg Mutation: 41 strains or lines available

References

• Original: J:91362 Tsai YS, et al., Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARgamma. J Clin Invest. 2004 Jul;114(2):240-9
• All: 8 reference(s)