Btn1a1^tm1Ihm
Targeted Allele Detail

Summary

• Symbol: Btn1a1^tm1Ihm
• Name: butyrophilin, subfamily 1, member A1; targeted mutation 1, Ian H Mather
• MGI ID: MGI:3050155
• Synonyms: BtnKO1
• Gene: Btn1a1 Location: Chr13:23641162-23650071 bp, - strand Genetic Position: Chr13, 9.72 cM
• Alliance: Btn1a1^tm1Ihm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91440
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The 3' part of exon 2 and the 5' part of intron 2 from nucleotides 5655 to 6519 were replaced with an IRES/lacz/SV40/MC1neo/pA reporter selection cassette. Southern blot confirmed recombination and Northern blot demonstrated lack of transcript in mutants. (J:91440)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Btn1a1 Mutation: 32 strains or lines available

References

• Original: J:91440 Ogg SL, et al., Expression of butyrophilin (Btn1a1) in lactating mammary gland is essential for the regulated secretion of milk-lipid droplets. Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):10084-9
• All: 1 reference(s)