Gstz1^tm1Pgb
Targeted Allele Detail

Summary

• Symbol: Gstz1^tm1Pgb
• Name: glutathione transferase zeta 1 (maleylacetoacetate isomerase); targeted mutation 1, Philip G Board
• MGI ID: MGI:3050206
• Synonyms: Gstz1^-
• Gene: Gstz1 Location: Chr12:87193939-87211497 bp, + strand Genetic Position: Chr12, 41.34 cM, cytoband E
• Alliance: Gstz1^tm1Pgb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91519
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: BALB/c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 6-8 were replaced with a neomycin resistance gene. PCR and Southern blot confirmed recombination in ES cells and Northern blot and Western blot indicated lack of transcript and protein in mutant organs. (J:91519)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Gstz1 Mutation: 23 strains or lines available

References

• Original: J:91519 Lim CE, et al., Mice deficient in glutathione transferase zeta/maleylacetoacetate isomerase exhibit a range of pathological changes and elevated expression of alpha, mu, and pi class glutathione transferases. Am J Pathol. 2004 Aug;165(2):679-93
• All: 2 reference(s)