Csk^tm1Tara
Targeted Allele Detail

Summary

• Symbol: Csk^tm1Tara
• Name: c-src tyrosine kinase; targeted mutation 1, Alexander Tarakovsky
• MGI ID: MGI:3050293
• Synonyms: csk^fl, csk^flox
• Gene: Csk Location: Chr9:57533929-57560758 bp, - strand Genetic Position: Chr9, 31.18 cM
• Alliance: Csk^tm1Tara page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:49654
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted in intron 8 and a floxed HSVtk-neo selection cassette was inserted in intron 10. The selection cassette was subsequently removed from properly targeted ES cells by transient cre expression leaving exons 9 and 10 flanked by loxP sites. (J:49654)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Csk Mutation: 27 strains or lines available

References

• Original: J:49654 Schmedt C, et al., Csk controls antigen receptor-mediated development and selection of T-lineage cells. Nature. 1998 Aug 27;394(6696):901-4
• All: 16 reference(s)