Cd151^tm1Lka
Targeted Allele Detail

Summary

• Symbol: Cd151^tm1Lka
• Name: CD151 antigen; targeted mutation 1, Leonie K Ashman
• MGI ID: MGI:3050539
• Synonyms: CD151-
• Gene: Cd151 Location: Chr7:141047305-141051386 bp, + strand Genetic Position: Chr7, 86.82 cM
• Alliance: Cd151^tm1Lka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91605
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A loxP site was inserted in the intron between exons 1c and 2 and a floxed neo cassette downstream of exon 7. Crossing with mice expressing Cre in the germ line excised exons 2-7 and the neo. Southern blot confirmed recombination and Northern blot and reverse transcription-PCR indicated lack of transcript in mutants. (J:91605)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Cd151 Mutation: 34 strains or lines available

References

• Original: J:91605 Wright MD, et al., Characterization of mice lacking the tetraspanin superfamily member CD151. Mol Cell Biol. 2004 Jul;24(13):5978-88
• All: 11 reference(s)