Zfp36l1^tm1Pjb
Targeted Allele Detail

Summary

• Symbol: Zfp36l1^tm1Pjb
• Name: zinc finger protein 36, C3H type-like 1; targeted mutation 1, Perry J Blackshear
• MGI ID: MGI:3050540
• Synonyms: L1^FLX, Zfp36L1^-
• Gene: Zfp36l1 Location: Chr12:80154534-80159787 bp, - strand Genetic Position: Chr12, 36.46 cM
• Alliance: Zfp36l1^tm1Pjb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91579
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 2 was interrupted by the insertion of a neo. Southern blot confirmed recombination and Northern blot of MEFs showed lack of transcript in mutants. (J:91579)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zfp36l1 Mutation: 10 strains or lines available

References

• Original: J:91579 Stumpo DJ, et al., Chorioallantoic fusion defects and embryonic lethality resulting from disruption of Zfp36L1, a gene encoding a CCCH tandem zinc finger protein of the Tristetraprolin family. Mol Cell Biol. 2004 Jul;24(14):6445-55
• All: 2 reference(s)