Matn2^tm1Asz
Targeted Allele Detail

Summary

• Symbol: Matn2^tm1Asz
• Name: matrilin 2; targeted mutation 1, Atilla Aszodi
• MGI ID: MGI:3050541
• Synonyms: Matn2^-
• Gene: Matn2 Location: Chr15:34306827-34436388 bp, + strand Genetic Position: Chr15, 13.98 cM, cytoband B3.3
• Alliance: Matn2^tm1Asz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91587
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An IRES-lacZ-neo cassette replaced exon 2b, which encodes the translation start site, the signal peptide and a positively charged region of the protein. Southern blot confirmed recombination and Northern blot indicated absence of transcript in mutant MEFs. (J:91587)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Matn2 Mutation: 55 strains or lines available

References

• Original: J:91587 Mates L, et al., Mice lacking the extracellular matrix adaptor protein matrilin-2 develop without obvious abnormalities. Matrix Biol. 2004 Jun;23(3):195-204
• All: 7 reference(s)