Tacc2^tm1Jni
Targeted Allele Detail

Summary

• Symbol: Tacc2^tm1Jni
• Name: transforming, acidic coiled-coil containing protein 2; targeted mutation 1, James N Ihle
• MGI ID: MGI:3050542
• Synonyms: Tacc2^-
• Gene: Tacc2 Location: Chr7:130179168-130366515 bp, + strand Genetic Position: Chr7, 73.19 cM, cytoband F4
• Alliance: Tacc2^tm1Jni page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91577
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 4 and exons 5-7 were replaced by a neomycin resistance gene. Southern blot confirmed successful recombination and Northern blot showed decreased levels of mRNA in heterozygotes and none in kidneys of homozygous mutants. (J:91577)

Tumor Data

List all tumor models in MMHCdb carrying Tacc2^tm1Jni

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tacc2 Mutation: 207 strains or lines available

References

• Original: J:91577 Schuendeln MM, et al., The centrosomal, putative tumor suppressor protein TACC2 is dispensable for normal development, and deficiency does not lead to cancer. Mol Cell Biol. 2004 Jul;24(14):6403-9
• All: 2 reference(s)