Ppp1r8^tm1Ave
Targeted Allele Detail

Summary

• Symbol: Ppp1r8^tm1Ave
• Name: protein phosphatase 1, regulatory subunit 8; targeted mutation 1, Aleyde Van Eynde
• MGI ID: MGI:3050545
• Synonyms: NIPP1^-
• Gene: Ppp1r8 Location: Chr4:132554240-132570480 bp, - strand Genetic Position: Chr4, 65.97 cM
• Alliance: Ppp1r8^tm1Ave page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91601
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 3.2 kb fragment of the promoter region and exons 1 and 2 were replaced with a neo cassette. Southern blot confirmed recombination and PCR confirmed recombination. (J:91601)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppp1r8 Mutation: 29 strains or lines available

References

• Original: J:91601 Van Eynde A, et al., The nuclear scaffold protein NIPP1 is essential for early embryonic development and cell proliferation. Mol Cell Biol. 2004 Jul;24(13):5863-74
• All: 6 reference(s)