Ccnb1ip1^mei4
Chemically induced Allele Detail

Summary

• Symbol: Ccnb1ip1^mei4
• Name: cyclin B1 interacting protein 1; prophase defect, John Schimenti
• MGI ID: MGI:3050548
• Synonyms: Hei10^mei4
• Gene: Ccnb1ip1 Location: Chr14:51026706-51033185 bp, - strand Genetic Position: Chr14, 26.25 cM
• Alliance: Ccnb1ip1^mei4 page

Meiosis is abnormal in Ccnb1ip1^mei4/Ccnb1ip1^mei4 male and female mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A G to T transversion is found at bp 298 counting from the start of the first coding exon (G298T). This is the 5' splice donor site at the 3' end of exon 1. This causes the use of a cryptic splice donor site 72 bp up stream at position 226 and leads to an in frame 24 amino acid deletion in the protein (amino acids 76-100) eliminating a putative cyclin/CDK interaction domain. (J:86161, J:125220)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccnb1ip1 Mutation: 22 strains or lines available

References

• Original: J:86161 Ward JO, et al., Toward the genetics of mammalian reproduction: induction and mapping of gametogenesis mutants in mice. Biol Reprod. 2003 Nov;69(5):1615-25
• All: 6 reference(s)