Clnk^tm1Vei
Targeted Allele Detail

Summary

• Symbol: Clnk^tm1Vei
• Name: cytokine-dependent hematopoietic cell linker; targeted mutation 1, Andre Veillette
• MGI ID: MGI:3050561
• Synonyms: Clnk^-
• Gene: Clnk Location: Chr5:38863805-39034155 bp, - strand Genetic Position: Chr5, 20.81 cM
• Alliance: Clnk^tm1Vei page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91590
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 5, the first exon common to all alternatively spliced transcripts, was disrupted by the insertion of a neo. Southern blot confirmed recombination and no wild-type or truncated transcripts were shown in Northern blot. Western blotting further confirmed lack of protein, truncated or full-length. (J:91590)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clnk Mutation: 31 strains or lines available

References

• Original: J:91590 Utting O, et al., Immune functions in mice lacking Clnk, an SLP-76-related adaptor expressed in a subset of immune cells. Mol Cell Biol. 2004 Jul;24(13):6067-75
• All: 1 reference(s)