Itga6^tm1Son
Targeted Allele Detail

Summary

• Symbol: Itga6^tm1Son
• Name: integrin alpha 6; targeted mutation 1, Arnoud Sonnenberg
• MGI ID: MGI:3050562
• Synonyms: alpha6A-, Itga6^loxP
• Gene: Itga6 Location: Chr2:71617236-71688761 bp, + strand Genetic Position: Chr2, 42.79 cM
• Alliance: Itga6^tm1Son page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50235
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutation: Intragenic deletion
• Mutation details: An exon containing coding sequence specific to the A isoform was deleted by replacement with a loxP-flanked neomycin cassette, followed by cre-mediated recombination in ES cells. This resulted in a single loxP site in place of the exon, and led to the exclusive expression of the B isoform in all tissues where the A isoform was normally expressed. (J:50235)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itga6 Mutation: 211 strains or lines available

References

• Original: J:50235 Gimond C, et al., Cre-loxP-mediated inactivation of the alpha6A integrin splice variant in vivo: evidence for a specific functional role of alpha6A in lymphocyte migration but not in heart development. J Cell Biol. 1998 Oct 5;143(1):253-66
• All: 6 reference(s)