Iqcg^esgd12d
Chemically induced Allele Detail

Summary

• Symbol: Iqcg^esgd12d
• Name: IQ motif containing G; male sterility, John Schimenti
• MGI ID: MGI:3050608
• Synonyms: G1-374-12, repro1, stubby12d
• Gene: Iqcg Location: Chr16:32834640-32876617 bp, - strand Genetic Position: Chr16, 23.55 cM
• Alliance: Iqcg^esgd12d page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a point mutation (T to A) in the consensus splice site at the end of exon 7. RT-PCR confirmed the production of two altered transcripts. MutA introduces a foreign amino acid codon from intron 7 sequences. Mut B leaves the open reading frame intact without the 54 amino acids encoded in exon 7. This allele is an extreme hypomorph due to the production of low levels of normally spliced product. (J:86161, J:218515)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Iqcg Mutation: 32 strains or lines available

References

• Original: J:86161 Ward JO, et al., Toward the genetics of mammalian reproduction: induction and mapping of gametogenesis mutants in mice. Biol Reprod. 2003 Nov;69(5):1615-25
• All: 3 reference(s)