Pim3^tm1Brn
Targeted Allele Detail

Summary

• Symbol: Pim3^tm1Brn
• Name: proviral integration site 3; targeted mutation 1, Anton Berns
• MGI ID: MGI:3050663
• Synonyms: Pim3^-
• Gene: Pim3 Location: Chr15:88746397-88749929 bp, + strand Genetic Position: Chr15, 44.36 cM
• Alliance: Pim3^tm1Brn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91592
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An IRES-betaGeo cassette replaced part of exon 3, exons 4 and 5 and part of exon 6. Southern blot confirmed recombination. RT-PCR indicated absence of mRNA. (J:91592)

Expression

In Mice Carrying this Mutation:

6 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pim3 Mutation: 6 strains or lines available

References

• Original: J:91592 Mikkers H, et al., Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors. Mol Cell Biol. 2004 Jul;24(13):6104-15
• All: 11 reference(s)