Plxnd1^tm1Joe
Targeted Allele Detail

Summary

• Symbol: Plxnd1^tm1Joe
• Name: plexin D1; targeted mutation 1, Jonathan A Epstein
• MGI ID: MGI:3050678
• Synonyms: plexinD1^-
• Gene: Plxnd1 Location: Chr6:115931772-115971966 bp, - strand Genetic Position: Chr6, 53.72 cM
• Alliance: Plxnd1^tm1Joe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91658
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first coding exon, containing the sema domain, was replaced with a floxed neo. Southern blot demonstrated correct targeting. In situ hybridization and immunohistochemistry indicated lack of transcript and protein, respectively, in mutant embryos and hearts. (J:91658)

Expression

In Mice Carrying this Mutation:	10 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plxnd1 Mutation: 87 strains or lines available

References

• Original: J:91658 Gitler AD, et al., PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development. Dev Cell. 2004 Jul;7(1):107-16
• All: 8 reference(s)