Gabpa^tm1Rist
Targeted Allele Detail

Summary

• Symbol: Gabpa^tm1Rist
• Name: GA repeat binding protein, alpha; targeted mutation 1, Sika Ristevski
• MGI ID: MGI:3050761
• Synonyms: Gapbalpha^-
• Gene: Gabpa Location: Chr16:84631813-84660667 bp, + strand Genetic Position: Chr16, 46.92 cM, cytoband C3-4
• Alliance: Gabpa^tm1Rist page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91600
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: An IRES-lacZ-neo-pA cassette was inserted to disrupt exon 2, the first coding exon. Southern blot and PCR confirmed recombination. Western blot indicates comparable levels of proteins in wild-type and heterozygous ES cells. (J:91600)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gabpa Mutation: 67 strains or lines available

References

• Original: J:91600 Ristevski S, et al., The ETS transcription factor GABPalpha is essential for early embryogenesis. Mol Cell Biol. 2004 Jul;24(13):5844-9
• All: 1 reference(s)