Gnas^tm1Jop
Targeted Allele Detail

Summary

• Symbol: Gnas^tm1Jop
• Name: GNAS complex locus; targeted mutation 1, Jo Peters
• MGI ID: MGI:3050794
• Synonyms: DeltaEx1A-DMR, Gnas^tm1Jop-mat, Gnas^tm1Jop-pat
• Gene: Gnas Location: Chr2:174126113-174188537 bp, + strand Genetic Position: Chr2, 97.89 cM, cytoband E1-H3
• Alliance: Gnas^tm1Jop page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91717
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 2.3 kb encompassing most of a differentially methylated region spanning 1A, 612 bp upstream of the promoter, was replaced with a floxed cassette containing Tkneo-pA, URA3 and tACE-Cre-pA. The cassette was deleted upon germ-line transmission, leaving a single loxP site. (J:91717)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gnas Mutation: 54 strains or lines available

Notes

ES cell line = MAC3.

References

• Original: J:91717 Williamson CM, et al., A cis-acting control region is required exclusively for the tissue-specific imprinting of Gnas. Nat Genet. 2004 Aug;36(8):894-9
• All: 4 reference(s)