Hrh3^tm1Kot
Targeted Allele Detail

Summary

• Symbol: Hrh3^tm1Kot
• Name: histamine receptor H3; targeted mutation 1, Hidehito Kotani
• MGI ID: MGI:3050799
• Synonyms: H3-
• Gene: Hrh3 Location: Chr2:179741258-179746264 bp, - strand Genetic Position: Chr2, 102.62 cM
• Alliance: Hrh3^tm1Kot page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80824
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 994 bp segment including exon 1 was replaced with a neo cassette via homologous recombination. Northern blot analysis confirmed the absence of mRNA expression from this allele. (J:80824)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hrh3 Mutation: 20 strains or lines available

References

• Original: J:80824 Takahashi K, et al., Targeted disruption of H3 receptors results in changes in brain histamine tone leading to an obese phenotype. J Clin Invest. 2002 Dec;110(12):1791-9
• All: 3 reference(s)