Met^tm2Cbm
Targeted Allele Detail

Summary

• Symbol: Met^tm2Cbm
• Name: met proto-oncogene; targeted mutation 2, Carmen Birchmeier
• MGI ID: MGI:3050810
• Synonyms: Met^flox
• Gene: Met Location: Chr6:17463799-17573979 bp, + strand Genetic Position: Chr6, 7.83 cM, cytoband A2
• Alliance: Met^tm2Cbm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91484
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 15 and a loxP-flanked neomycin selection cassette was in serted into intron 15. Transient Cre expression in ES cells excised the selection cassette from intron 15, leaving exon 15 surrounded by loxP sites. Recombination was verified by Southern blot. (J:91484)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Met Mutation: 83 strains or lines available

References

• Original: J:91484 Borowiak M, et al., Met provides essential signals for liver regeneration. Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10608-13
• All: 7 reference(s)