Tg(HLA-A2/H2-K)1Scr
Transgene Detail

Summary

• Symbol: Tg(HLA-A2/H2-K)1Scr
• Name: transgene insertion 1, The Scripps Research Institute
• MGI ID: MGI:3050815
• Synonyms: CyHLA A2.1/Kb
• Transgene: Tg(HLA-A2/H2-K)1Scr Location: unknown
• Alliance: Tg(HLA-A2/H2-K)1Scr page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(HLA-A2/H2-K)1Scr expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	H2-K (MGI:3040519)

• Mutation details: The transgene expresses a human-mouse chimeric major histocompatibility class I protein composed of the leader sequence and the alpha1 and alpha2 domains of HLA-A2.1 joined to the alpha3, cytoplasmic and transmembrane domains of H2-K^b. Mice expressing this transgene exhibit HLA-A2.1-restricted CD8 T-cell responses to appropriate antigens. (J:91744)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:91745 Sherman LA, C57BL/6J mice with MHC class I-H2 chimeric transgene can be used to identify HLA-A2.1 restricted peptide epitopes. MGI Direct Data Submission. 2004
• All: 8 reference(s)