Tg(MMTV-Erbb2)NF1Mul
Transgene Detail

Summary

• Symbol: Tg(MMTV-Erbb2)NF1Mul
• Name: transgene insertion NF1, William Muller
• MGI ID: MGI:3050869
• Synonyms: MMTV-ErbB2^Act, TG.NF
• Transgene: Tg(MMTV-Erbb2)NF1Mul Location: unknown
• Alliance: Tg(MMTV-Erbb2)NF1Mul page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(MMTV-Erbb2)NF1Mul expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Erbb2 (24337)

  Erbb2

  (MGI:95410)

• Mutation details: This transgene contains the MMTV (mouse mammary tumor virus) promoter and a 4.6 kb cDNA from the rat Erbb2 (avian erythroblastosis B2) oncogene. The activated form of the gene is used in this construct, which differs from the wild-type allele by a point mutation, Val664Glu. Six transgenic lines were produced (NA, NB, NF, NK, NL and NM). (J:48632)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(MMTV-Erbb2)NF1Mul

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Multiple transgenic lines were produced, including NA1 and NK1.

References

• Original: J:48632 Muller WJ, et al., Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene. Cell. 1988 Jul 1;54(1):105-15
• All: 6 reference(s)