Tg(MMTV-Erbb2)NK1Mul
Transgene Detail

Summary

• Symbol: Tg(MMTV-Erbb2)NK1Mul
• Name: transgene insertion NK1, William Muller
• MGI ID: MGI:3050871
• Synonyms: HER-2/neu, MMTV c-neu, MMTV-c-neu, MMTV-erbB2, MMTV-neu, MMTV-Tg.NK, Tg(MMTV-Erbb2)1Led, TG.NK
• Transgene: Tg(MMTV-Erbb2)NK1Mul Location: unknown
• Alliance: Tg(MMTV-Erbb2)NK1Mul page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(MMTV-Erbb2)NK1Mul expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Erbb2 (24337)

  Erbb2

  (MGI:95410)

• Mutation details: This transgene contains the MMTV (mouse mammary tumor virus) LTR promoter, a 4.6 kb cDNA from the rat Erbb2 (avian erythroblastosis B2) oncogene, and an SV40 polyadenylation site sequence. The activated form of the rat gene is used in this construct, which differs from the wild-type allele by a point mutation, Val664Glu. Non-uniform and random transgene expression is detected by RNase protection assay in mammary gland epithelium from hemizygous transgenic mice. Six transgenic lines were produced (NA, NB, NF, NK, NL and NM). (J:48632)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(MMTV-Erbb2)NK1Mul

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Tumor formation in transgenic mice is multifocal, stochastic, and matches the expression pattern of the transgene. While no transgene expression is detected at 5 and 8 weeks of age in normal mammary gland tissue, expression is detected in adenocarcinomas from older (23 week old) mice. 50% of transgenic mice derived from this founder line develop tumors within 6-12 months of age.

References

• Original: J:48632 Muller WJ, et al., Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene. Cell. 1988 Jul 1;54(1):105-15
• All: 114 reference(s)