St8sia2^tm1Jxm
Targeted Allele Detail

Summary

• Symbol: St8sia2^tm1Jxm
• Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2; targeted mutation 1, Jamey Marth
• MGI ID: MGI:3051219
• Synonyms: St8sia-II-
• Gene: St8sia2 Location: Chr7:73588867-73663408 bp, - strand Genetic Position: Chr7, 42.27 cM
• Alliance: St8sia2^tm1Jxm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91777
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 4, encoding a significant portion of the sailyl motif L, was deleted upon Cre mediated deletion of the floxed region including the exon and a tk-neo cassette. Southern blot confirmed recombination and RT-PCR indicated that the truncated form of mRNA was produced in heterozygous and homozygous mutants. The mutant cDNA was found to be inactive. (J:91777)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any St8sia2 Mutation: 23 strains or lines available

References

• Original: J:91777 Angata K, et al., Sialyltransferase ST8Sia-II assembles a subset of polysialic acid that directs hippocampal axonal targeting and promotes fear behavior. J Biol Chem. 2004 Jul 30;279(31):32603-13
• All: 29 reference(s)