Ptcra^tm1Vbo
Targeted Allele Detail

Summary

• Symbol: Ptcra^tm1Vbo
• Name: pre T cell antigen receptor alpha; targeted mutation 1, Harald von Boehmer
• MGI ID: MGI:3051255
• Synonyms: pTalpha^-
• Gene: Ptcra Location: Chr17:47066589-47074638 bp, - strand Genetic Position: Chr17, 22.9 cM, cytoband D-E1
• Alliance: Ptcra^tm1Vbo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:26493
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 and 4, which encode the connecting peptide, the transmembrane region, the cytoplasmic tail, and most of the 3' UTR were replaced with a neo cassette. Correct recombination was confirmed by Southern blot. (J:26493)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptcra Mutation: 16 strains or lines available

References

• Original: J:26493 Fehling HJ, et al., Crucial role of the pre-T-cell receptor alpha gene in development of alpha beta but not gamma delta T cells. Nature. 1995 Jun 29;375(6534):795-8
• All: 47 reference(s)