Hoxd11^tm2.1Ddu
Targeted Allele Detail

Summary

• Symbol: Hoxd11^tm2.1Ddu
• Name: homeobox D11; targeted mutation 2.1, Denis Duboule
• MGI ID: MGI:3051383
• Synonyms: Hoxd-11^RVIIIGe2
• Gene: Hoxd11 Location: Chr2:74509902-74517360 bp, + strand Genetic Position: Chr2, 44.13 cM
• Alliance: Hoxd11^tm2.1Ddu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:41828
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Hoxd11^tm2Ddu mice were crossed with mice expressing Cre in the germline, thereby excising the floxed neo in progeny. This allele contained an FRT site in place of the endogenous RVIII region and one loxP site in the insertion site of the neo cassette. (J:41828)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxd11 Mutation: 14 strains or lines available

References

• Original: J:41828 Zakany J, et al., Deletion of a HoxD enhancer induces transcriptional heterochrony leading to transposition of the sacrum. EMBO J. 1997 Jul 16;16(14):4393-402
• All: 4 reference(s)